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After you send STOP, you may receive a confirmation message indicating that you have been unsubscribed. After your opt-out request is processed, you will no longer receive SMS messages from that messaging program unless you opt in again.
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Changes to These SMS Terms
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You’ll receive reminder emails for the next LGS CME/CE session, including full access details.
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Earn up to 1.5 AMA PRA Credit
The OX2R Era Is Here. Is Your NT1 Diagnosis?
Phoenix, AZ | October 18, 2026 | 12:00 - 1:15 Phoenix Time
Learning Objectives
- Identify the full NT1 symptom pentad and the systemic clinical burden of orexin deficiency.
- Apply the cataplexy interrogation question at the CPAP non-response encounter.
- Differentiate NT1 from NT2, idiopathic hypersomnia, and common misdiagnoses using the defining diagnostic criterion of cataplexy or CSF hypocretin-1 <110 pg/mL.
- Distinguish NT1 from medication-induced and primary psychiatric EDS using ICSD-3 criteria when psychiatric comorbidity complicates evaluation of excessive daytime sleepiness.
- Apply evidence-based PSG/MSLT diagnostic protocols, including medication washout requirements, SOREMP interpretation, and CSF hypocretin-1 <110 pg/mL as a standalone NT1 diagnostic criterion per ICSD-3.
- Integrate SDoH-informed screening, navigator referral pathways, and telehealth-compatible approaches to reduce diagnostic delay in NT1 across diverse patient populations.
- Individualize NT1 treatment selection using an SDM framework informed by the limitations of current pharmacotherapy and the mechanism of emerging OX2R-directed therapies.
Accredited Provider


Joint Accreditation Statement

Physician Credit Designation
Nurse Contact Hours Designation
Global Education Group designates this continuing education activity for 1.5 contact hour(s) including 0.0 pharmacotherapeutic contact hour(s).
Faculty, Staff, and Planners’ Disclosures
Disclosure of Unlabeled Use
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Disclaimer
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Disclosures of Relevant Financial Relationship(s)
The faculty have the following relevant financial relationships with ineligible companies:
Disclosures
University of California
La Jolla, CA
Disclosures
Volunteer Peer Support Group Facilitator, Wake Up Narcolepsy Oklahoma City, Oklahoma
Disclosures
Instructions to Receive Credit
A statement of credit will be issued within four weeks of receipt of a completed activity evaluation form.
Fee Information and Refund/Cancellation Policy
Global Contact Information
System Requirements
Program Overview
Target Audience
The primary audience for this activity includes pulmonologists, sleep specialists, primary care physicians, internists, hospitalists, nurse practitioners, physician assistants, and respiratory therapists involved in the diagnosis and management of narcolepsy.
Supporter Acknowledgement
Use of artificial intelligence in this activity
How the AI is controlled.
The AI does not search the internet. It does not give you diagnostic or treatment recommendations. Before release, the faculty and the IridiumCE and Global Education Group planners, tested the simulation for accuracy, completeness, balance and freedom from commercial bias on October 12, 2026.
Platform: Patient dialogue is generated using OpenAI's GPT-4.1 model (gpt-4.1-2025-04-14). The patient's video avatar is powered by HeyGen.
Independence. Global, as the accredited provider, is responsible for all content in this activity, including what the AI generates.
Data. All conversation and scores are recorded so we can give personalized feedback, award credit, and evaluate and improve the activity.
Pre-Meeting Simulation: The OX2R Era Is Here. Is Your NT1 Diagnosis?
AI Simulation: The OX2R Era Is Here. Is Your NT1 Diagnosis?