Despite a multitude of treatment options targeting 3 well-characterized pathologic pathways in PAH, this progressive, life-threatening condition continues to have an overall poor prognosis, with 3-year mortality up to 55% in high-risk patients. Diagnostic delay continues to be a barrier to timely treatment initiation. Racial and ethnic disparities, as well as social determinants of health, may play a role in diagnostic delay. HCPs must be equipped with the knowledge and tools to recognize and address the potential contributors to diagnostic delay. The diagnostic interval may be shortened through improved screening of PAH patients with known risk factors, earlier referrals for specialists and earlier diagnostic testing, including TTE, and improved EMR documentation. A number of novel therapeutic agents, including those targeting previously unaddressed pathways, are being tested in PAH. HCPs must be made aware of those agents in late-stage clinical trials which may have a future in the treatment landscape as synergistic, relatively convenient options that may help optimize patient outcomes, particularly those experiencing negative SDoH.