Primary biliary cholangitis (PBC) a chronic and progressive autoimmune liver disease that can lead to cirrhosis if unrecognized and untreated. In this educational activity, PBC experts will address knowledge and competence barriers related to disease pathophysiology, early recognition and diagnosis, long-term disease monitoring, and pharmacologic treatment. Clinical practice guidelines and approved and emerging therapies will be explored. A focus of the program will be second-line therapies and how that appropriate advancement through the treatment pathways may improve real-world outcomes.