Podcast series with ACCOMPANYING med ed threads

Advancing Worsening Heart Failure Treatment: Exploring Cutting-Edge Therapies and Addressing Disparities

Overview
Learning Objectives
Faculty and Disclosures

Program Overview

HFrEF is a progressive and complex condition with very high rates of mortality and hospitalizations. Recently, positive cardiovascular (CV) outcomes and reduced hospitalization for heart failure (HF) were noted in patients with HF with reduced ejection fraction (HFrEF) treated with novel emerging agents. The inclusion of the soluble guanylate cyclase (sGC) stimulator, vericiguat; and the sodium-glucose cotransporter-2 (SGLT2), empagliflozin and dapagliflozin; have revolutionized the treatment of patients with HFrEF. The treatment of HFrEF requires one or more drugs from several classes, as recommended in the guidelines. Many factors need to be considered when selecting therapy for these patients, including how to initiate, add, or switch therapies, and how to assess the effectiveness of these treatments using imaging and biomarkers. Recent additions to guidelines including SGLT2 inhibitors and vericiguat have the potential to significantly decrease risk for hospitalization for patients with HFrEF. Timely implementation of these therapies is critical to achieve the anticipated health benefits.

Target Audience

This educational initiative is designed for cardiologists, preventive cardiologists, emergency department (ED) physicians, and all clinicians interested in managing patients with heart failure.

Learning Objectives

Upon completion of this activity, the participant should be able to:
  • Describe the diagnosis and prognosis of worsening heart failure.
  • Describe innovative medical and device-based strategies for prevention or treatment of worsening HF
  • Summarize the novel HF medications and their treatment indications for HFrEF and HFpEF.
  • Discuss health disparities in the diagnosis and treatment of HF and strategies to reduce these disparities.

Disclosures of Relevant Financial Relationship(s)

​Global Education Group (Global) adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Global are required to disclose all financial relationships with any ineligible company within the past 24 months to Global. All financial relationships reported are identified as relevant and mitigated by Global in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Global to assure objectivity and that the activity is free of commercial bias.

All relevant financial relationships have been mitigated.

The faculty have the following relevant financial relationships with ineligible companies:
Deepak Bhatt, MD, MPH, FACC, FAHA, FESC, MSCAI
Director of Mount Sinai Heart; Dr. Valentin Fuster Professor of Cardiovascular Medicine
Icahn School of Medicine at Mount Sinai
New York, NY
Disclosures:
Consulting Fee (e.g., Advisory Board): Angiowave, Bayer, Boehringer Ingelheim, Broadview Ventures, CellProthera, Cereno Scientific, Hims, Janssen, McKinsey, Merck, MyoKardia, NirvaMed, Novo Nordisk, PhaseBio, PLx Pharma, SFJ, Stasys, Youngene
Contracted Research (Principal Investigators must provide information, even if received by the institution): Abbott, Acesion Pharma, Afimmune, Aker Biomarine, Alnylam, Amarin, Amgen, AstraZeneca, Bayer, Beren, Biotronik, Boehringer Ingelheim, Boston Scientific, Bristol-Myers Squibb, Cardax, CellProthera, Cereno Scientific, Chiesi, CinCor, Cleerly, CSL Behring, CSI, Eisai, Endotronix, Ethicon, Faraday Pharmaceuticals, Ferring Pharmaceuticals, Forest Laboratories, Fractyl, Garmin, HLS Therapeutics, Idorsia, Ironwood, Ischemix, Janssen, Javelin, Lexicon, Lilly, Medtronic, Merck, Moderna, MyoKardia, NirvaMed, Novartis, Novo Nordisk, Otsuka, Owkin, Pfizer, PhaseBio, Philips, PLx Pharma, Recardio, Regeneron, Roche, Sanofi, SpectraWAVE, Stasys, St. Jude Medical (Abbott), Svelte, The Medicines Company, Youngene, Vascular Solutions, 89Bio
Honoraria: CSL Behring, MJH Life Sciences
Stock Shareholder (Individual stocks/Stock options; diversified mutual funds do not need to be disclosed): Bristol Myers Squibb
Stock Option Holder (Individual stocks/Stock options; diversified mutual funds do not need to be disclosed): Angiowave, DRS.LINQ
Other: Board of Directors: Angiowave, Bristol Myers Squibb, DRS.LINQ
Data Monitoring Committees: Acesion Pharma, Boston Scientific, Novartis
Patent: Sotagliflozin (named on a patent for sotagliflozin assigned to Brigham and Women's Hospital who assigned to Lexicon)
Erin Michos,
MD, MHS
Director of Women Cardiovascular Health Research
Associate Director of Preventive Cardiology at Johns Hopkins University School of Medicine
Co-Director, IMPACT Center at Johns Hopkins University
Co-Editor in Chief, American Journal of Preventive Cardiology
Baltimore, MD
Disclosures:
Consulting Fee (e.g., Advisory Board):
Amgen, AstraZeneca, Boehringer Ingelheim, Edwards Lifescience, Esperion, Medtronic, Merck, Novartis, Novo Nordisk, New Amsterdam, Pfizer
This educational activity was supported by an independent educational grant from
Merck, Sharpe, and Dohme, LLC.

Learning program contents